Coronary artery disease (CAD) or ischaemic heart disease caused by atherosclerosis is the most common form of cardiovascular disease. CAD leads to acute coronary syndrome which is the clinical syndrome caused by new or growing interruption or occlusion of blood supply to a part of the heart, causing heart cells to die and myocardial infarction. Patient after myocardial infarction is at great cardiovascular risk and has high possibility of next cardiovascular incidents, such as myocardial infarction, stroke or cardiovascular death. Correct treatment of patient after myocardial infarction facilitates cardiovascular risk reduction and improves the prognosis. Secondary prevention after myocardial infarction includes non-pharmacological management– modification of life style – and pharmacological treatment. The most important is elimination of risk factors: smoking cessation, proper control of blood pressure, normalization of cholesterol level, reduction of overweight and regular physical activity. Patient awareness and physician commitment are essential for achieving beneficial effects of secondary prevention after myocardial infarction. This paper describes the recommendations for patient after myocardial infarction as far as non-pharmacologic and pharmacologic treatment according to contemporary guidelines are concerned. There are specific situations, such as concomitant diseases: hypertension, diabetes, left ventricle dysfunction and heart failure, chronic kidney disease, chronic obstructive pulmonary disease that require modified approach.