The article discusses the effect of synbiotic therapy on the qualitative and quantitative changes in colonic microbiota in preschool children with community-acquired pneumonia. A total of 33 children aged from 1 to 3 years were included in the study. All patients were divided into two groups. The first group consisted of 17 children who received standard therapy. The second group consisted of 16 patients, whose treatment was supplemented with a synbiotic preparation at a dose of one sachet per day. The assessment of colonic microbiota was conducted in 33 patients with community-acquired pneumonia before treatment and on treatment days 12–14. The control group consisted of 20 healthy age and sex-matched children. Bacteriological study of gut microflora was conducted using the Epshtein-Lytvak method. The evaluation of the microflora composition changes in children suffering from community-acquired pneumonia showed an intensification of gut microflora imbalance after standard therapy. When studying the effectiveness of the synbiotic preparation in patients with community-acquired pneumonia, it was found that the state of colon microbiocenosis in patients who received complex therapy with synbiotic drug significantly improved compared to children treated with standard regimen. Thus, of the use of synbiotic therapy in patients with community-acquired pneumonia improves or fully restores gut microflora in some cases. This preparation can serve as a safe and convenient way to restore gut microflora balance and prevent the development of gastrointestinal pathologies.