Moderately-differentiated neuroendocrine carcinoma of the larynx: a case report and literature review
1 Department of Otorhinolaryngology, Hospital Sultanah Aminah, Malaysia
2 Department of Pathology, Hospital Sultanah Aminah, Malaysia
3 Department of Otorhinolaryngology – Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
Correspondence: Chok Tong Khaw, Department of Otorhinolaryngology, Hospital Sultanah Aminah, Jalan Abu Bakar, 80100 Johor Bahru, Johor, Malaysia, tel.: 60138181510, e-mail:
Pediatr Med Rodz 2019, 15 (4), p. 412–415
DOI: 10.15557/PiMR.2019.0071

Laryngeal neuroendocrine carcinoma is a rare tumour of the larynx, accounting for only about 1% of all primary laryngeal tumours. Laryngeal neuroendocrine carcinomas are classified as well-, moderate- and poorly-differentiated neuroendocrine carcinoma. The differentiating features of each category include nuclear atypia, mitotic rate and presence or absence of necrosis. Immunochemistry stains also help in diagnosing laryngeal neuroendocrine carcinoma. In this article, we present a case report of moderately-differentiated neuroendocrine carcinoma of the larynx in a 57-year-old man who presented with neck pain and dysphagia persisting for one month. There is no standard treatment regimen for laryngeal neuroendocrine carcinoma. However, due to the poor prognosis for moderately-differentiated laryngeal neuroendocrine carcinomas, we advocate aggressive and prompt treatment and surveillance PET-CT scan 6 months postoperatively.

Keywords: immunohistochemistry (IHC), larynx, neuroendocrine carcinoma (NEC), laryngectomy