Numerous disease entities may present with myalgia, involving just one muscle group or many muscles (polymyalgia, polymyositis). Apart from trauma, myalgia may be caused by infectious agents, including viruses, Gram-positive, Gramnegative, anaerobic or atypical bacteria, fungi or parasites. Individual history and laboratory findings are crucial for the diagnosis. Once diagnosed, myalgia is treated with proper medication, rehabilitation and/or other methods. We report a case of a 4-year-old female patient hospitalised due to lower extremity pain and impaired gait, with a prodrome of sore throat, rhinitis, cough and pustular rash. Laboratory findings facilitated the diagnosis of a mixed, viral-bacterial aetiology, with tailored treatment promptly initiated, resulting with the patient’s quick recovery. This study highlights the need for a comprehensive diagnostic workup in cases of childhood myalgia to identify the aetiologic agent, allowing to introduce targeted therapy, and thus facilitate speedy recovery.